Projects and Opportunities

Below, you can explore our projects which are available for co-development or licensing. Technology offers can be searched using categories below or by inserting of your keywords in the search box, upper right corner of this page.

Biotechnologies

DIANA

Enzyme detection and inhibitor screening

easy living cell DNA labeling

Autors: Tomas Kraus and Zbigniew Zawada     Challenge Labeling of nucleic acids, DNA in particular, with fluorescent reagents is one of the essential methods in their investigation and in cell cycle analysis. Currently, it is performed by incubation of cells with commercially available BrdU or EdU, followed by cell fixation and a treatment with […]

iBodies – modular synthetic antibodies

Modular synthetic antibodies – iBodies can be customized for your needs. Contact us for more information!

LentiKats Laccase Production System

for large scale production of the enzyme laccase using Lentikats Biocatalyst

Single-use LentiKat’s copper detection Kit

Simple kit for fast and easy detection of the content of copper (Cu2+) ions in drinking water and industrial waste-waters

Infection

Lipophosphonoxins, new antibiotics overcoming bacterial resistance

Lipophosphonoxins exhibit significant antibacterial activity in particular against gram-positive bacteria including resistant strains. Advantage of these compounds consists in simple synthesis and their modular structure allowing for further optimization of their biological properties.

Wild bee venom peptides, novel antimicrobial and antifungal compounds

Novel antimicrobial peptides (AMPs) from the venom reservoirs of wild bees promis robust solution for topic bacterial and fungal infection preventing further development of resistance.Beside human medicine other applications of AMPs are higly promissing such as use in dermatology, beauty industry, intimate hygiene or surface disinfection.

Inflammation

Novel anti-inflammatory compounds

Ulcerative colitis or rheumatoid arthritis are diseases causing chronic inflammation (either in colon or in joints), which (in the long term) stays behind tissue destruction resulting in pathological changes, pain and loss of tissue function. Novel pyrimidine derivatives were proved for significant positive healing effects after p.o. application using animal models of rheumatoid arthritis and ulcerative colitis (acute or chronic).

Neurology

Neurosteroids, potent CNS therapeutics – SMART Steroids

A number of studies demonstrated a neuroprotective ability of NMDA receptor (NMDAR) antagonists. Our results demonstrated that naturally occurring 3α5β-pregnanolone sulfate has a more pronounced inhibitory action on the tonically active NMDAR and common side effects of NMDA antagonist were disprooved in animal models.

Oncology

Helquats, c-myc downregulation small molecules

We developed a novel class of selective G-quadruplex stabilizing ligands – helquats, which show promising bioactivity at low micromolar concentration in cell based assays. The helquat derivatives exhibit antiproliferative activity in selected cancer cell lines over-expressing c-myc and show an encouraging toxicity profile comparable to those of quarfloxin.

Selective Carbonic anhydrase IX inhibitors

Selective Carbonic anhydrase IX (CAIX) inhibitors: a new opportunity for therapy and/or diagnostics of cancer diseases. Selective inhibitors of CAIX were identified among promising candidates for solid tumor treatment. Inhibiton of CAIX (expressed only in tumor tissue) cause hypoxia and begin apoptosis of tumor cells, while normal tissue not expressing CAIX remains unaffected.